Abstract
Abstract The effectiveness of a coating pan in treating all the contained tablets identically depends upon its being a good mixing device; the mechanics of particle motion within such a pan are therefore of interest. One measure of the mixing rate in rotary drum mixers is the coefficient of self diffusion, a parameter difficult to measure in a coating pan. Three methods of measuring such a coefficient are reported and compared: linear sampling, total compartmenting of the bed, and high speed cinéphotography. The third method is the best, and a technique is described for treating the pictorial data to obtain quantitative results.
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