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Abstract
Osteoarthritis is a chronic degenerative disease that dampens the quality of life of those who suffer it. Conventional treatments are palliative, they are targeted to reduce joint pain. However, more efforts are needed to find new therapies that are able to positively affect or at least stop the course of this degenerative disease. Amongst the different therapeutic options that are being studied, collagen emerges as a good candidate due to its safety and preclinical and clinical evidence. Two different approaches have been taken for collagen: collagen hydrolysates and native collagen.
Highlights
Osteoarthritis is a chronic degenerative joint disease, where the cartilage progressively gets degraded
Research studies have shown that both types of collagen nutraceuticals are effective in reducing osteoarthritis pain, in animal models and in human clinical trials, through different mechanisms of action
Collagen improved the urinary levels of CTX-I and CTX-II as well as the hand radiological score after 1 year of treatment [21]. Another clinical study where knee osteoarthritis patients consumed for 6 months undenatured collagen showed a reduction in WOMAC score improving pain and joint functionality [22]
Summary
Osteoarthritis is a chronic degenerative joint disease, where the cartilage progressively gets degraded. Research studies have shown that both types of collagen nutraceuticals are effective in reducing osteoarthritis pain, in animal models and in human clinical trials, through different mechanisms of action. There are several drugs that can be used for osteoarthritis, but they are mainly effective reducing pain but not improving the underneath cause, cartilage destruction.
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