Abstract
Objective: The purpose of this study was to develop a nanoemulgel containing vegetable oil of carrot seed oil as an effective natural sunscreen and skin anti-aging. Methods: Nanoemulgels containing 4% carrot seed oil were formulated in three formulas with different ratios of Tween 80 and Sorbitol and prepared by using the high-energy emulsification method. The nanoemulgels were determined for the organoleptic characteristic, globule size, pH, physical stability during storage for 12 w at three different temperatures (room, high and low temperature), centrifugation, and cycling test. The Sun Protection Factor (SPF) value was determined by UV spectrophotometric method and the effectiveness of anti-aging was evaluated by using a skin analyzer and the results were compared with sunscreen emulgel. Results: Nanoemulgel containing 4% carrot seed oil with a ratio of Tween 80 as surfactant and Sorbitol as co-surfactant 40 and 20 resulted in the smallest mean droplet size of 338.34 nm and the sizes were increased during 12 w of storage at room temperature but still in the nano size and this nanoemulgel did not show phase separation or still stable. These nanoemulgels were also stable after the centrifugation and cycling test. The emulgel preparation was not stable or showed phase separation after the centrifugation test. The SPF value obtained from the nanoemulgel was 20.28±0.22 and these values were higher than the sunscreen emulgel (13.94±0.27). The pore size, spot, and wrinkles of the volunteer skin were reduced after using the nanoemulgel containing 4% carrot seed. Conclusion: The sunscreen and skin anti-aging activity of nanoemulgel preparation containing 4% carrot seed oil with a ratio of surfactant Tween 80 and co-surfactant Sorbitol 40 and 20 were more effective compare with emulgel preparation.
Highlights
UV radiation in the skin induces oxidative free radicals, such as superoxide, hydrogen peroxide, and highly reactive hydroxyl radicals that strongly attack macromolecules such as proteins, lipids, RNA, and DNA, changing their structure and interfering with their function, which can cause oxidative stress [1]
The use of sunscreen is necessary for the precautions recommended by dermatologists and public health campaigns aimed at reducing sunburn, premature skin aging, and skin cancer [4]
The nanoemulgel containing carrot seed oil obtained in this study had a smaller droplet size than the emulgel formulation
Summary
UV radiation in the skin induces oxidative free radicals, such as superoxide, hydrogen peroxide, and highly reactive hydroxyl radicals that strongly attack macromolecules such as proteins, lipids, RNA, and DNA, changing their structure and interfering with their function, which can cause oxidative stress [1]. The use of sunscreen is necessary for the precautions recommended by dermatologists and public health campaigns aimed at reducing sunburn, premature skin aging, and skin cancer [4]. The use of natural sunscreen ingredients such as carrot seed oil can reduce this effect. Carrot seed oil is an antioxidant, antiseptic, antifungal, and fragrant with a high vitamin A content and can be used as a sunscreen, anti-aging, skin revitalizing, and rejuvenating ingredient [7, 8]. Topical administration of preparation containing active ingredients from natural ingredients provides sunscreen and skin anti-aging effects with a broad spectrum, namely the effect of sunscreen on UV radiation and as antioxidant might help to reduce the reactive oxygen species causes of aging [9]. Nanotechnology has become a technology that can improve the stability and efficiency of cosmetic preparation [10]
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