Abstract
Abstract A gas chromatographic (GC) method involving the use of a capillary column and methylattng agents for the qualitative analysis of ten barbiturates has been developed. The method includes the use of a hydrogen flame ionization detector (FID), a 15.24 m × 0.76 mm stainless steel capillary column coated with OV-17 stationary phase, and two methylating agents, trimethylanilinium hydroxide (TMAH) and methyl iodide (MI) in the presence of potassium carbonate as a condensing agent. The results obtained with this method were compared to a standard GC technique. Improved results from the use of MI and a mixed solvent system, acetone/methanol, rather than acetone alone, were observed. Applications of this technique to clinical samples have been made.
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