Abstract
It has been well recognized that the modification of biomaterials with appropriate bioactive peptides could further enhance their functions. Especially, it has been shown that peptide-modified bone repair materials could promote new bone formation more efficiently compared with conventional ones. The purpose of this article is to give a general review of recent studies on bioactive peptide-modified materials for bone tissue repair. Firstly, the main peptides for inducing bone regeneration and commonly used methods to prepare peptide-modified bone repair materials are introduced. Then, current in vitro and in vivo research progress of peptide-modified composites used as potential bone repair materials are reviewed and discussed. Generally speaking, the recent related studies have fully suggested that the modification of bone repair materials with osteogenic-related peptides provide promising strategies for the development of bioactive materials and substrates for enhanced bone regeneration and the therapy of bone tissue diseases. Furthermore, we have proposed some research trends in the conclusion and perspectives part.
Highlights
The biomaterials community has increasingly embraced the concept that implanted substrates should provide structural support for damaged tissues, and integrate with the surrounding tissues and promote the desired tissue regeneration [1,2,3]
The results showed the copolymer with higher eugenyl methacrylate (EgMA) content could immobilize a larger amount of REDV peptide
Reyes et al [29] investigated into the osteogenic functions of bone marrow stromal cells on the titanium surfaces modified by GFOGER peptide in vitro
Summary
The biomaterials community has increasingly embraced the concept that implanted substrates should provide structural support for damaged tissues, and integrate with the surrounding tissues and promote the desired tissue regeneration [1,2,3]. Some biomaterials do not readily adsorb blood proteins to their surface, and do not support well bone-related cell activities, potentially leading to limited bone formation These materials need to be further optimized to enhance and accelerate bone ingrowth [7]. Its capacity of supporting bone growth is approved by several studies, such as stimulating osteoblast proliferation and differentiation by enhancing cell attachment to bone repair materials and upregulating ECM production [15, 16]. The Asp-Gly-Glu-Ala (DGEA) that is a kind of collagen peptide can bind to a2b1 integrin, which is an extracellular matrix receptor for collagens and/or laminins, and promote cell adhesion, spreading and osteogenic differentiation [33]. These peptides have been mainly derived from BMP-2, BMP-7 and BMP-9 to promote bone-
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
