Abstract
Bone regeneration strategy to repair bone defects shows great potential.Although the skeleton has a strong self-healing and repair capabilities, for huge bone defect caused by trauma, congenital malformations, infection and surgery, the skeleton is difficult to complete the self-repairing process.In order to promote bone regeneration, bone growth must be induced by biologically active implants, cell and intracellular molecular signaling pathways.Mesenchymal stem cells (MSC) play an important role in bone repair and remodeling.Understanding the role of MSC and signaling pathways in bone repair and regeneration is critical for the study and development of bone repair materials. Key words: Bone Regeneration; Bone Defect; Mesenchymal Stem Cells; Signaling Pathway
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