Abstract
Background: Stroke affects up to 10% of individuals with sickle cell anemia (SCA), and its development has been linked to excessive intravascular hemolysis and arterial thrombosis Increased intracerebral blood flow (CBF) velocity as measured by the transcranial Doppler ultrasonography (TCD) identifies children with SCA with an increased risk of development of stroke. This study measured antithrombin (AT) levels among SCA patients as a predictor of TCD risk groups for the development of stroke. Materials and Methods: A total of 180 participants consisting of 135 SCA patients and 45 age-matched hemoglobin phenotype AA (HbAA) controls were enrolled into the study. CBF velocity was measured with TCD and results were used to classify the SCA group into standard risk, conditional risk, and high risk. AT functional activity, prothrombin time (PT), and activated partial thromboplastin time (APTT) of all participants were measured. Statistical tools including independent t-test, analysis of variance, Pearson's correlation, hierarchical multiple regression, and forward liner regression were used to analyze all continuous variables. P
Published Version
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