Abstract
Aqueous solutions of ephedrine give practically quantitative yields of the N-acetyl derivative by the action of acetic anhydride in the presence of excess bicarbonate. Under the same conditions procaine appears to acetylate at its primary amino group to yield a product which is basic by virtue of its tertiary nitrogen. The wide difference in properties of the acetyl derivatives of the two drugs permits their separation by simple extraction procedures, and the gravimetric determination of ephedrine as its acetyl derivative. The presence of small amounts of bisulfite greatly hinders the acetylation of ephedrine. The presence of ephedrine does not interfere in the determination of procaine by bromination.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Pharmaceutical Sciences (Scientific Edition)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
