Abstract
An adhesive made of concentrated human fibrinogen produced from samples of single donor blood by a simple cryoprecipitation method was tested for its ability to bond lamellar corneal buttons in vitro and found to have a bond strength of 140 gm/cm2. The adhesive was successfully used to attach experimental epikeratophakia grafts in a rabbit model. The results were similar to those reported from an earlier trial using a commercially available adhesive prepared from pooled multi-donor human plasma. This experimental trial of single-donor adhesive demonstrates the possibility of successful use of autologous fibrinogen adhesive in human epikeratophakia. Autologous adhesive would remove the possible threat of transmitted disease posed by multi-donor adhesive and avoid immune reactions to foreign proteins.
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