Abstract
SUMMARY Previous techniques used to evalute the efficiency of elimination of bacteria during voiding have involved the indirect measurement of the eliminated bacteria or determinations of fluid residual. We have developed a new technique for directly evaluating this voiding efficiency using external radionuclide scanning of bacteria-like 99 m. technetium sulphur colloid particles. We have studied the bladder clearance of these particles in 15 patients mimicking bacteriostatic conditions, and have mathematically corrected the data to simulate various bacterial growth rates. Routine diagnostic procedures failed to show bladder dysfunction in 11 subjects evaluated with recurring urinary tract infections, however, our study was able to define difficulties in particle (and presumably bacteria) elimination in 5 of these patients.
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