Abstract
(1) An amino acid (glycine, tryptophan, aspartic acid, arginine, serine, threonine, isoleucine, methionine, valine, or histidine) was injected intraperitoneally into adult mice, and the uptake by the brain was measured at various time periods. There was no uptake of glycine and aspartate; that of the other amino acids was appreciable. The rate of increase was different for the various amino acids. (2) Uptake was concentration dependent; increasing plasma, valine, and histidine concentrations slightly resulted in brain levels above those of plasma. Although uptake increased with higher plasma levels, the decreasing brain-plasma concentration ratio at higher concentrations indicated a saturable component of uptake. (3) Uptake of one amino acid was inhibited by related compounds; the pattern of inhibition indicated the presence of transport classes in vivo similar to those found in brain slices. Interaction of amino acids was further shown by the effect of the administration of one amino acid on the cerebral levels of a number of other compounds. (4) The individual differences in the behavior of the various amino acids emphasizes the role that specific transport processes play in cerebral homeostasis and metabolism in the living brain.
Published Version
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