Abstract
The types of capillaries in rabbit oral mucosa and major salivary glands have been identified, and their permeability to macromolecules, ferritin and thorotrast has been studied. The capillary network of the oral mucosa consisted of continuous and fenestrated capillaries. The fenestrated capillaries constituted a small proportion of the capillary bed in the oral mucosa of rabbit and were predominant in the parotid and submaxillary glands.The transport of ferritin and thorotrast across the endothelial cells occurred through pinocytotic vesicles, the markers being found occasionally in both dense bodies and multivesicular bodies. The marginal folds found projecting on the luminal surface of the endothelial cells may have a collaborating role in pinocytosis. Moreover, a concentration gradient was apparent along the fenestrated endothelial barrier where the bridging diaphragms separate the high density on the vascular lumen from the scattered particles in the extravascular connective tissue. Where the marker particles were noted apparently traversing endothelial fenestrae, the bridging diaphragms were not clearly identified. The basement lamina surrounding the endothelial cells acted as a temporary barrier to thorotrast but did not restrict the passage of ferritin.
Published Version
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