Abstract
The uptake of [ 35S]methimazole by sheep thyroid slices has been shown to be activated in the presence of iodide. The total uptake ( Q) of [ 35S]methimazole was shown to be the sum of a saturable process and a non-saturable process. The constants Q max, K s and P in the two-term equation were determined using a published statistical method and a Fortran IV computer programme. Diiodotyrosine (DIT) at a 0.1 mM concentration stimulated the saturable uptake of [ 35S]methimazole appreciably in the absence of iodide, whilst thyroid-stimulating hormone (TSH) inhibited uptake in the presence of iodide and was of no effect in the absence of iodide. Propylthiouracil (PTU) inhibited the saturable uptake of [ 35S]methimazole whilst perchlorate had no effect.
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