Abstract
The comparative effects of sodium iodide and TSH, in vitro, upon the oxidation of glucose-l-14C and upon triphosphopyridine nucleotide levels in slices of dog, rat, beef and sheep thyroid glands are reported. While TSH increased glucose oxidation in all these species, Nal, in concentrations of 1 × lO-3M and 1 × 1O-4M, produced consistent and statistically significant stimulation only in sheep thyroid slices. In the sheep, the effect of Nal in Krebs-Ringer phosphate buffer was equivalent to that of TSH. The levels of TPN in dog and beef thyroid incubated in Krebs- Ringer bicarbonate buffer were increased when TSH was added to the medium, while the changes attributable to Nal were inconstant. In sheep thyroid slices the changes in TPN in the presence of both TSH and Nal were small and inconstant even in those experiments in which there was a clear-cut stimulation of glucose oxidation. It was concluded that the effect of TSH upon glucose oxidation in thyroid slices is not mediated by TSH-induced release of i...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
