Abstract
The talk will briefly cover why there was a need for modifying the original Gleason grading system. Multiple images will be presented covering the variations of different Gleason grade patterns and certain pitfalls in grading. Grading of variants of prostate cancer, such as foamy gland cancer, pseudohyperplastic cancer, ductal adenocarcinoma, cancer with vacuoles, mucinous carcinomas, and small cell carcinoma will be presented. The grading of cancer with mucinous fibroplasia as Gleason pattern 3 in most cases and cancer with glomeruloid features as Gleason pattern 4 will be discussed. Issues relating to grading needle biopsy when there is either a lower grade or higher present to a limited extent will be covered, as will the topic of tertiary grade patterns on needle biopsy and radical prostatectomy. Finally, the presentation will end with a brief review of prognostic information relating to the different Gleason grade patterns including a new Prognostic Grade Grouping.
Published Version
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