The United States and Afghanistan: A Diminishing Transactional Relationship

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The United States has a long and varied history of engagement with Afghanistan. But through all the tortuous turns and ups and downs, the relationship, from the U.S. perspective, has almost always been a transactional one. Given its front line status, Afghanistan has usually been a pawn in a bigger strategic game, initially between the Communist bloc and the capitalist countries in the region (including Iran under the shah, Pakistan, and India) and subsequently between the secular world and radicalized Islam. Afghanistan's current status as a ward of the United States and international community is unusual and will not last.This essay suggests that regardless of whether a bilateral security agreement (BSA) is signed between Afghanistan and the United States, and assuming Afghanistan does not again become a haven for terrorism targeting the United States, U.S. interest will diminish. So too will U.S. resources invested in the country-whether military, economic, developmental, or diplomatic. Neighboring powers, such as India, Iran, and Pakistan, who have an immediate stake in a secure, stable Afghanistan, will become more important players. Long memories, the need for strategic depth, and the fear that Afghan soil will once again become a battleground for proxy warfare will militate against the realization of the Afghan government's vision of the country as the peaceful and prosperous heart of Asia.The History of U.S. Engagement in AfghanistanA brief review of the relationship between the United States and Afghanistan is instructive. Following World War II, the United States and the Soviet Union competed to maintain influence with Afghan rulers, as the British and Russian Empires had done in the previous century, using modest levels of technical, military, and development assistance-the Great Game once again played out in Afghanistan. After the invasion of 1979, the United States sought to undermine Soviet power by supporting the mujahideen, using Pakistani security forces as the delivery mechanism. Once the Soviet Union left in 1989 and the Najibullah regime collapsed in 1992, Afghanistan dropped off the U.S. radar until the Taliban swept into Kabul in 1996. Then followed a period in which the United States had an ambivalent relationship with Afghanistan: not recognizing the Islamic emirate that controlled 90% of the country, but intermittently engaging with its authorities through intermediaries on specific issues; providing some humanitarian support through the United Nations and the Red Cross/Red Crescent; encouraging private-sector interest in a pipeline across the country; and expressing concern about women's rights.All that changed with September 11. Having decisively ejected the Taliban in a lightning military campaign, the United States promoted a Western and largely multilateral agenda to stabilize and reconstruct the country and rebuild its institutions and economy. But by 2006, as the Taliban reasserted their presence and security began once again to deteriorate, the United States had moved to a counterinsurgency approach. By 2009 and the Obama administration's surge, this had mushroomed into a full-blown military and state-building campaign with an annual price tag over $120 billion-perhaps the most ambitious the world has seen in the last 50 years.Next Steps in U.S.-Afghanistan Relations: The Short TermU.S. engagement in Afghanistan will continue to evolve. In the short to medium term, much depends on whether a BSA between Afghanistan and the United States is signed. As for the longer term, predictions are unwise, but the country's strategic importance to the United States is likely to diminish unless Afghanistan once again becomes an incubator for transnational terrorism.Afghanistan with a BSA. If a BSA is signed, there is no guarantee that Afghanistan will continue to be a recipient of exceptional levels of U.S. assistance-currently higher in per capita terms than any other country excepting Israel1-but the prospects will be stronger that the administration will have enough political support to honor the pledges it made in Chicago and Tokyo for military and civilian support, respectively, until 2016. …

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Abstract P1-11-20: Chemotherapy use in patients with early-stage high-risk ER+/HER2- breast cancer in the United States (US) community setting: A retrospective observational cohort study
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  • Clinical Cancer Research
  • Peter Fasching + 6 more

Background: Novel options for perioperative systemic anticancer immunotherapy are currently being evaluated for early-stage high-risk ER+/HER2– breast cancer, for example, neoadjuvant pembrolizumab plus chemotherapy (chemo) followed by adjuvant pembrolizumab plus endocrine therapy in the phase 3 KEYNOTE-756 trial (NCT03725059). This retrospective cohort study aimed to describe patient characteristics and chemo treatment patterns in this patient population overall and based on chemo receipt status. Methods: This study used the Syapse Learning Health Network, a database capturing the continuum of care for patients treated at US community practices, to select adults (≥18 years) with initial diagnosis (1/1/2016 – 1/30/2023) of high-risk (grade 3 AND T1c–T2/cN1–cN2 or T3–T4/cN0–cN2) ER+/HER2– breast cancer who had first surgery at the primary site, as in KEYNOTE-756, with latest data up to 05/31/2024. Patients enrolled in a clinical trial or with lobular carcinoma in situ, lymphoma, or other primary cancer were excluded. Using descriptive statistical tests, we compared baseline characteristics between patients who received chemo in the neoadjuvant and/or adjuvant setting and those who did not receive chemo. Real-world time on treatment (rwToT) with neoadjuvant and adjuvant chemo was estimated using Kaplan-Meier curves. Results: Of 16,998 adults with HR+/HER2– nonmetastatic breast cancer at diagnosis, 441 patients (2.6%) with high-risk ER+/HER2– breast cancer (clinical stage I/II/III: 4%/55%/41%) underwent surgery and were eligible for the analyses. Median age was 55 years (range 23–89); 99% were women (60% postmenopausal); 68% were White; 95% (n=160) with known performance status had ECOG 0/1. Ductal carcinoma was most common (91%). Overall, 7% had ER-low positivity; 89% had positive clinical nodal status (cN1/N2: 81%/8%); and 69% were PR+. Of the 16% (n=71) with available Oncotype DX score, 42% scored high (>25), 31% intermediate (18–25), and 27% low (<18). Of the 44% (n=192) with available data, 7% were documented to have a germline BRCA mutation. Of 441 patients, 400 (91%) received systemic therapy in the neoadjuvant and/or adjuvant setting. About 78% of the cohort (346/441) received chemo, including 71% (n=244) in neoadjuvant, 23% (n=78) in adjuvant, and 7% (n=24) in both settings. Chemo recipients, compared with chemo non-recipients (22%; n=95), were relatively younger (median [range]: 53 years [23–84] vs. 68 years [30–89]; p<0.001) and less often postmenopausal women (55% vs. 78%; p<0.001) with Medicare insurance (19% vs. 53%). Several baseline clinical characteristics differed significantly between chemo recipients and chemo non-recipients, including clinical stage III (44% vs. 29%; p=0.03), node-positive status (92% vs. 79%; p<0.001), ductal carcinoma tumor histology (93% vs. 84%; p=0.02), and Oncotype Dx high RS (61% vs. 10%; p<0.005). Median follow-up time was 26.2 months (range: 1.1–87.9). Among patients who received neoadjuvant only (n=69) or adjuvant only chemo (n=19), rwToT was 4.1 months (95% CI, 3.7–4.4) and 2.5 months (2.1–4.5), respectively. Conclusions: In this real-world study among patients with early-stage high-risk ER+/HER2– breast cancer, approximately 3 out of every 4 patients received chemo in the neoadjuvant and/or adjuvant setting. Younger patients with more advanced tumor stage and node-positive status were more likely to receive chemo than older patients with less advanced tumor stage and node-negative status. Our future work will describe more details of chemotherapy use and its impact on clinical outcomes, characterizing the unmet need in this high-risk patient population. Citation Format: Peter Fasching, Jagadeswara Rao Earla, Yezhou Sun, Kim M Hirshfield, Yu-Han Kao, Giovanna I Cruz, Amin Haiderali. Chemotherapy use in patients with early-stage high-risk ER+/HER2- breast cancer in the United States (US) community setting: A retrospective observational cohort study [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P1-11-20.

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