Abstract
The following utrastructural modifications were noticed in a group of 28 diabetic and 2 normal individuals: a) a rather patchy endothelial proliferation with b) frequent hypertrophy which occasionally arrives to obliterate the sinusoidal lumen; c) increased number of cytoplasmic organelles and lysosomes, big and irregular nuclei; d) numerous and various in shape pseudopodic cellular prolongations; e) reduced number of pynocytoticcaveolae intracellulares; f) a certain dilatation of the rough ergastoplasmic reticulum. Comparison was made with the changes noticed in the same patient in the peripheric capillaries (biopsies of the calf) and a functional study of the reticuloendothelial system of the liver (nicotinic acid i.v. test) was carried out. The existence of the diabetic microangiopathy in the liver is discussed as part of the known diabetic vascular changes described in the peripheric capillaries and the possibility of micro-ischaemic disturbances in the liver itself is suggested.
Published Version
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