Abstract
Cardio-vascular specialists have witnessed and actively participated in the revolutionary developments that have occurred in their field of specialization over the last few years. Cutting-edge technologies have led to dramatic improvements in life-expectancy and quality of life. An open-mind and pioneering attitude are necessary when exploring new frontiers to improve our patients’ health. However, naive indiscriminate acceptance of novel mainstream therapies is not always advisable and prudence is required in unearthing harmful, covert side effects. An objective review of contemporary vascular research was performed and industrial bias was sifted out for a fresh prospective on how to promote primary cardiovascular prevention with attainable lifestyle adjustments [1]. A comprehensive review of Pubmed, EMBASE and Cochrane review databases was undertaken for articles relating to cardiovascular primary prevention and statin side effects with the aim of harmonising their roles within contemporary clinic practice. Particular attention was paid to large-scale randomised controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular primary prevention and regenerative programmes. There is a categorical lack of clinical evidence to support the use of statin therapy in primary prevention. Not only is there a dearth of evidence for primary cardiovascular protection, there is ample evidence to show that statins actually augment cardiovascular risk in women, patients with Diabetes Mellitus and in the young. Furthermore statins are associated with triple the risk of coronary artery and aortic artery calcification. Cardiovascular primary prevention and regeneration programmes, through life style changes and abstaining from tobacco use have enhanced clinical efficacy and quality of life over any pharmaceutical or other conventional intervention.
Highlights
The endovascular revolution has brought about unprecedented changes in our cardiovascular practice over the last twenty five years
Is there a dearth of evidence for primary cardiovascular protection, there is ample evidence to show that statins augment cardiovascular risk in women, patients with Diabetes Mellitus and in the young
We performed a comprehensive review of Pubmed, EMBASE and Cochrane review databases for articles relating to cardiovascular primary prevention, statin side effects, and pharmacotherapies with the aim of harmonising their roles within contemporary clinic practice
Summary
The endovascular revolution has brought about unprecedented changes in our cardiovascular practice over the last twenty five years. The finding in a Cochrane systemic review by Taylor et al is alarming [3] They reviewed the current concept of the use of statins in primary prevention and found evidence of selective reporting of outcomes, failure to report adverse events and inclusion of people with cardiovascular disease. The results of contemporary trials in cardiovascular medicine have challenged current practice, and have forced physicians to do a u-turn on their primary prevention practices [4]. What this highlights is the need for repeated guideline appraisals and revisions and the need for skillful clinical judgment [1]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
