Abstract
This report demonstrates that changing the position of the carbon-metal bond in a polypyridyl cyclopalladated complex, i.e. going from PdL1 (N^N^C^N) to PdL2 (N^N^N^C), dramatically influences the photodynamic properties of the complex in cancer cells. This effect is primarily attributed to the significantly difference in absorbance and singlet oxygen quantum yields between the two isomers.
Highlights
Xue-Quan Zhou, a Anja Busemann, a Michael S
This report demonstrates that changing the position of the carbon– metal bond in a polypyridyl cyclopalladated complex, i.e. going from PdL1 (N^N^C^N) to PdL2 (N^N^N^C), dramatically influences the photodynamic properties of the complex in cancer cells
We investigated the design and properties of palladium(II) photodynamic therapy (PDT) sensitizers built from single tetradentate cyclometallating ligands, which are expected to be more stable in biological media compared with the tridentate N-heterocyclic carbene ligands
Summary
Xue-Quan Zhou, a Anja Busemann, a Michael S. This report demonstrates that changing the position of the carbon– metal bond in a polypyridyl cyclopalladated complex, i.e. going from PdL1 (N^N^C^N) to PdL2 (N^N^N^C), dramatically influences the photodynamic properties of the complex in cancer cells.
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