Abstract
The gene for the human transcription factor forkhead related activator 2 (FREAC-2; HGMW-approved symbol FKHL6) has been characterized and found to consist of two exons separated by an intron of 3.6 kb. The first exon encodes the forkhead DNA-binding domain and one of the transcriptional activation domains, AD2. The second exon contains the coding sequence corresponding to the C-terminal activation domain AD1. The full-length FREAC-2 protein is predicted to be 444 amino acids, which adds 39 amino acids to the previously published partial cDNA sequence. A 2-kb CG island is centered around the 5′ end of theFREAC-2gene. Fluorescencein situhybridization was used to localize the humanFREAC-2gene to chromosomal position 6p24–p25, and the localization was further refined by radiation hybrid mapping to 6p25.3.
Published Version
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