Abstract
1. 1. An affinity chromatography technique for the determination of turnover parameters has been applied to the study of carbonic anhydrase in a variety of mouse tissues. 2. 2. The methodology has allowed the establishment of the relative turnover characteristics in these tissues, and the evaluation of the half lives and degradation rate constants. 3. 3. Considerable variation was evident between the individual tissues, with synthesis being indicated as most rapid in intestine while degradation was highest in liver. 4. 4. These data have been discussed in relation to available comparisons in the literature, and the known physiological correlations of carbonic anhydrase in these tissues.
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