The treatment zone size and its decentration influence axial elongation in children with orthokeratology treatment

Weiping Lin,Na Li,Chunyu Tang,Guihua Liu,Ruihua Wei,Bei Du,Tianpu Gu

doi:10.1186/s12886-021-02123-x

Weiping Lin, Na Li + Show 5 more

Open Access

https://doi.org/10.1186/s12886-021-02123-x

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Abstract

BackgroundTo investigate whether the treatment zone size (TZS) and treatment zone decentration (TZD) will affect the axial elongation in myopic children undergoing orthokeratology treatment.MethodsA self-controlled retrospective study was conducted on 352 children who met the inclusion criteria. Axial length was measured before and at 12 months after the initial lens wear. Corneal topography was measured at baseline and at each follow-up after lens wear. The Corneal topography obtained from the 12-month visit was used to quantify TZS and TZD for each subject. Cycloplegic refraction was required for all children before fitting the orthokeratology lenses.ResultsAxial elongation was significantly associated with age, baseline spherical equivalent (SE), TZS, and TZD with univariate linear regression. In groups with both small and large TZS, axial elongation was significantly decreased with large TZD (both P < 0.01). In groups with both small and large TZD, axial elongation was significantly decreased with small TZS (P = 0.03 for small TZD, P = 0.01 for large TZD). Age, SE, and TZD were significantly associated with axial elongation in multiple regression (all P < 0.01).ConclusionRelatively smaller TZS and larger TZD may be beneficial in slowing myopia progression in children with orthokeratology treatment.

Highlights

To investigate whether the treatment zone size (TZS) and treatment zone decentration (TZD) will affect the axial elongation in myopic children undergoing orthokeratology treatment
Axial elongation was significantly associated with age and baseline spherical equivalent (SE) (Fig. 2A, B)
Axial elongation was significantly associated with TZS (Fig. 2D) and TZD (Fig. 2C)

Summary

Introduction

To investigate whether the treatment zone size (TZS) and treatment zone decentration (TZD) will affect the axial elongation in myopic children undergoing orthokeratology treatment. Myopia has increased in prevalence to 20–30% in western countries and 40–70% in Asian populations [3, 4]. In East Asian countries, 80% of 18-yearolds are myopic [5]. Progression of myopia, with axial elongation and eyeball expansion, increased the risk of a series of myopia pathological changes, such as macular. A variety of methods have been used for controlling the progress of myopia, including orthokeratology, which has an effectiveness supported by several studies [8,9,10,11]. Relative corneal refractive power in the mid-peripheral cornea is increased, inducing myopic defocus on the peripheral retina.

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