The treatment of refractory glaucoma with modified trabeculectomy combined with biological amniotic membrane transplantation and mitomycin C

Abstract

Objective To evaluate the clinical effect of modified trabeculectomy combined with biological amniotic membrane transplantation and mitomycin C for the treatment of refractory glaucoma. Methods Thirty-two eyes of 30 patients with refractory glaucoma were randomly divided into the combined therapy group and the control group. In combined therapy group, after performing modified trabeculectomy and mitomycin C, biological amniotic membrane was implanted under the sclera flap. In control group, only traditional trabeculectomy was proformed. Visual acuity, filtering bleb and intraocular pressure were compared between two groups at pre-operation and 1week, 1 month, 6 months and 1 year after the operation. Results There was no statistically significant difference in visual acuity between two groups at 1 week after the operation. At 6 months and 1 year after the operation, cases with functional filtering bleb in the combined therapy group were more than that in control group. At 1 week, 6 months and 1 year after the operation, the intraocular pressure in combined therapy group was lower than that in control group, and the differences were statistically significant. Conclusion Modified trabeculectomy combined with biological amniotic membrane transplantation and mitomycin C is effective for the treatment of refractory glaucoma. Key words: Glaucoma, refractory; Trabeculectomy, modified; Amnion, biological; Mitomycin C