The treatment of cryptococcal meningitis with amphotericin B, a new fungicidal agent.

Abstract

Article1 August 1958THE TREATMENT OF CRYPTOCOCCAL MENINGITIS WITH AMPHOTERICIN B, A NEW FUNGICIDAL AGENTMARTIN J. FITZPATRICK, M.D., HARRY RUBIN, M.D., CHARLES M. POSER, M.D.MARTIN J. FITZPATRICK, M.D.Search for more papers by this author, HARRY RUBIN, M.D.Search for more papers by this author, CHARLES M. POSER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-249 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIn recent years there has been a growing medical awareness of the prevalence of chronic systemic fungus infections, many of which are worldwide in distribution.1In addition to the more readily apparent cutaneous and osseous infections, deep mycotic infections involving the pulmonary, renal, gastrointestinal and central nervous systems are being reported with increasing frequency.2During this time the continuing introduction of potent antibiotics and their enlarging clinical use have resulted in apparent control of many important bacterial infections, with a shifting spectrum of infectious diseases in many communities. As a result of this changing background, chronic fungus infections have...Bibliography1. ConantSmithBakerCallawayMartins NFDTRDJLDS: Manual of clinical mycology, 2nd Ed., 1954, W. B. Saunders Co., Philadelphia. CrossrefGoogle Scholar2. LittmanZimmerman MLLE: Cryptococcosis, 1956, Grune & Stratton, New York, p. 3. Google Scholar3. Versé M: Über einen Fall von generalisierter Blastomykose beim Menschen, Verhandl. d. deutsch. path. Gesellsch. 17: 275, 1914. Google Scholar4. StoddardCutler JLEG: Torula infection in man, Monographs of the Rockefeller Institute for Medical Research. No. 6., 1, 1916. Google Scholar5. SteinbergJamborSuydam BAWPLO: Amphotericins A and B: two new antifungal antibiotics possessing high activity against deep-seated and superficial mycoses, in Antibiotics annual 1955-1956, 1956, Medical Encyclopedia, Inc., New York, p. 574. Google Scholar6. WettingfeldRoweEyles RFJDE: Treatment of toxoplasmosis with pyrimethamine (Daraprim) and triple sulfonamide, Ann. Int. Med. 44: 557, 1956. LinkGoogle Scholar7. SmithVollum HVRL: Effect of intrathecal tuberculin and streptomycin on tuberculous meningitis, Lancet 2: 275, 1950. CrossrefMedlineGoogle Scholar8. GoldStoutPaganoDonovick WHAPGR: Amphotericins A and B, antifungal antibiotics produced by a streptomycete. I. In vitro studies, in Antibiotics annual 1955-1956, 1956, Medical Encyclopedia, Inc., New York, p. 579. Google Scholar9. VandeputteWachtelStiller JJLET: Amphotericins A and B, antifungal antibiotics produced by a streptomycete. II. The isolation and properties of the crystalline amphotericins, in Antibiotics annual 1955-1956, 1956, Medical Encyclopedia, Inc., New York, p. 587. Google Scholar10. SternbergWrightCura THETM: A new antifungal antibiotic, amphotericin B, in Antibiotics annual 1955-1956, 1956, Medical Encyclopedia, Inc., New York, p. 566. Google Scholar11. AppelbaumShtokalko ES: Cryptococcus meningitis arrested with amphotericin B, Ann. Int. Med. 47: 346, 1957. LinkGoogle Scholar12. RubinLehanFitzPatrickFurcolow HPJMJML: Amphotericin B in the treatment of cryptococcal meningitis, in Antibiotics annual 1957-1958, Medical Encyclopedia, Inc., New York, in press. Google Scholar13. Littman M: Personal communication. Google Scholar14. FitzPatrick MJ: The treatment of tuberculous meningitis, Am. Rev. Tuberc. 69: 370, 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kansas City, Kansas*Received for publication February 11, 1958.From the Department of Medicine, University of Kansas School of Medicine, and the Kansas City Field Station, Public Health Service, Department of Health, Education, and Welfare, University of Kansas Medical Center, Kansas City, Kansas.Requests for reprints should be addressed to Martin J. FitzPatrick, M.D., Department of Medicine, University of Kansas Medical Center, Kansas City 12, Kansas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byO líquido cefalorraquiano inicial nas meningencefalites por Cryptococcus neoformansCriptococose do sistema nervoso central: experiência atual do Serviço de Neurologia da Escola Paulista de MedicinaCryptococcosisCryptococcosisCryptococcal (torular) retinitisEncephalitisCryptococcal meningitis in Hong KongThe Improved Prognosis of Cryptococcal Meningitis with Amphotericin B TherapyANDERSON SPICKARD, M.D., WILLIAM T. BUTLER, M.D., VINCENT ANDRIOLE, M.D., JOHN P. UTZ, M.D., F.A.C.P.MykosenAntibiotics 1956–1961Systemic Blastomycosis Recurrent Neurological Relapse in a Case Treated with Amphotericin BR. G. LOUDON, M.B., CH.B., M.R.C.P.E., ROY A. LAWSON JR., M.D.Current Status of Griseo-fulvin and Amphotericin BDie AntimykoticaFATAL TOXIC REACTION TO AMPHOTERICIN B IN CRYPTOCOCCAL MENINGO-ENCEPHALITIS*BALDO M. CARNECCHIA, M.D., JOHN F. KURTZKE, M.D.PULMONARY CRYPTOCOCCOSIS: TREATMENT WITH AMPHOTERICIN B*JOHN R. DURANT, LEONARD D. EPIFANO, SIMON W. EYERCRYPTOCOCCUS NEOFORMANS INFECTION OF THE CENTRAL NERVOUS SYSTEM: A CASE TREATED BY AMPHOTERICIN B, WITH POSTMORTEM EXAMINATION*JOSEPH M. STEIN, M.D., PHYLLIS J. BURDON, M.D.Cryptococcosis (Torulosis)North American blastomycosisCurrent status of amphotericin B in the treatment of the systemic fungus infections 1 August 1958Volume 49, Issue 2Page: 249-259KeywordsCryptococcal meningitisGastrointestinal infectionsHistoplasma capsulatumInfectious disease controlInfectious diseasesMedical educationMedical servicesMeningitisPulmonary diseasesStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 August 1958 PDF downloadLoading ...