Cryptococcus neoformans infection of the central nervous system: a case treated by amphotericin B, with postmortem examination.

Abstract

Case Reports1 February 1960CRYPTOCOCCUS NEOFORMANS INFECTION OF THE CENTRAL NERVOUS SYSTEM: A CASE TREATED BY AMPHOTERICIN B, WITH POSTMORTEM EXAMINATIONJOSEPH M. STEIN, M.D., PHYLLIS J. BURDON, M.D.JOSEPH M. STEIN, M.D.Search for more papers by this author, PHYLLIS J. BURDON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-445 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the well documented increase in the number of recognized cases of infection byCryptococcus neoformans,7renewed interest has been directed toward treatment. The discovery of amphotericin B5initiated the use of a promising antifungal antibiotic in clinical practice. Some recent reports of its use in cases of cryptococcus infections of the central nervous system have engendered guarded optimism,2, 10, 1, 4, 8but follow-up studies are still limited in time. The patient to be described was known to us for a total of nine years, and his cryptococcus infection was recognized and treated in its early stages for more...Bibliography1. AppelbaumShtokalko ES: Cryptococcus meningitis arrested with amphotericin B, Ann. Int. Med. 47: 346-351, 1957. LinkGoogle Scholar2. BiddleKoenig AH: An agent effective against cryptococcosis of the central nervous system, Arch. Int. Med. 102: 801-805, 1958. CrossrefGoogle Scholar3. BoshesShermanHesserMilzerMacLean LDICCJAH: Fungus infections of the central nervous system, Arch. Neurol. and Psychiat. 75: 175-197 (Feb.) 1956. CrossrefGoogle Scholar4. FitzpatrickRubinPoser MJHCM: The treatment of cryptococcal meningitis with amphotericin B, a new fungicidal agent, Ann. Int. Med. 49: 249-259, 1958. LinkGoogle Scholar5. GoldStoutPaganoDonovik WHAJFR (a) : Amphotericins A and B, antifungal antibiotics produced by a streptomycete. I. In vitro studies, in Antibiotics Annual 1955-1956, edited by Welch and Marti-Ibanez, 1956, Medical Encyclopedia, Inc., New York, pp. 579-586. (b) Vandeputte, J., Wachtel, J. L., and Stiller, E. T.: Amphotericins A and B, antifungal antibiotics produced by a streptomycete. II. The isolation and properties of the crystalline amphotericins, in Antibiotics Annual 1955-1956, edited by Welch and Marti-Ibanez, 1956, Medical Encyclopedia, Inc., New York, pp. 587-591. (c) Steinberg, B. A., Jambor, W. P., and Suydam, L. O.: Amphotericins A and B: two new antifungal antibiotics possessing high activity against deep-seated and superficial mycoses, in Antibiotics Annual 1955-1956, edited by Welch and Marti-Ibanez, 1956, Medical Encyclopedia, Inc., New York, pp. 574-578. (d) Sternberg, T. H., Wright, E. T., and Oura, M.: A new antifungal antibiotic, amphotericin B, in Antibiotics Annual 1955-1956, edited by Welch and Marti-Ibanez, 1956, Medical Encyclopedia, Inc., New York, pp. 566-573. Google Scholar6. Levine S: Experimental cryptococcosis (torulosis) (New York Neurological Society and New York Academy of Medicine, Section of Neurology and Psychiatry), Arch. Neurol. and Psychiat. 78: 477, 1957. Google Scholar7. LittmanZimmerman MLLE: Cryptococcosis, 1956, Grune and Stratton, New York. Google Scholar8. MartinNicholsSvienUlrich WJDRHJJA: Cryptococcosis, Arch. Int. Med. 104: 4-14 (July) 1959. CrossrefGoogle Scholar9. McCulloughLouriaHilbishThomasEmmons NBDBTFLBC: Cryptococcosis, Ann. Int. Med. 49: 642-661, 1958. LinkGoogle Scholar10. RubinFurcolow HMD: Promising results in cryptococcal meningitis, Neurology 8: 590-595 (Aug.) 1958. CrossrefMedlineGoogle Scholar11. SciortinoMacHaffieAllibandAzzyer ALRAGRRL: Cryptococcosis, Arch. Int. Med. 102: 450-458, 1958. CrossrefGoogle Scholar12. WarrenStephensCrow WAGGEW: Cryptococcosis, treatment of two cases with stilbamidines, J. Kansas M. Soc. 58: 301-303, 1957. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Topeka, Kansas*Received for publication October 26, 1959.From the Medical and Neurological Service, Veterans Administration Hospital, Topeka, Kansas.Requests for reprints should be addressed to Joseph M. Stein, M.D., The Menninger Clinic, Topeka, Kansas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemotherapy of the Systemic MycosesCryptococcose, Morbus Hodgkin und Toxoplasmose mit NekropsieCryptococcosisCryptococcosisErfolgreiche Amphotericin B-Behandlung einer Cryptococcose der Haut und des ZentralnervensystemsDie Antibiotica 1 February 1960Volume 52, Issue 2Page: 445-453KeywordsAmphotericinCentral nervous systemCryptococcosisCryptococcus neoformansDrugsLymphomaMedical servicesMeningitisResearch laboratoriesSpondylitis Issue Published: 1 February 1960 PDF downloadLoading ...