The treating dogs for enteropathy with PLE

Abstract

One of the most common and poorly understood diseases in dogs and cats is enteropathy with PLE. The disease occurs, according to studies, in dogs of 2-6 years old breeds: Yorkshire terrier, German shepherd, and Golden Retriever. The disease in most cases is manifested by anorexia, polydipsia, diarrhea, fever up to 39.7 °C, tachycardia (145–170 bpm), and abdominal pain. In sick dogs, leucocytosis (21.0 ± 0.50 g/l), thrombocytosis (480.0 ± 10.13 g/l), oligocythaemia (4.8 ± 0.12 T/l), oligochromemia (109.0 ± 5.06 g/l), decrease in haematocrit value (29.0 ± 1.21 % in healthy people 42.3 ± 0.65 %). In a biochemical study of blood in dogs with enteropathy with PLE, hypoproteinaemia (38.2 ± 0.65 g/l), hypoalbuminemia (9.6 ± 0.61 g/l); hyperazotemia (8.6 ± 0.37 mmol/l), hypercholesterolemia (8.0 ± 0.23 mmol/l), hyperenzymemia of LF (ALP) and ALT (alanine aminotransferase), hyponatremia, hypokalaemia, hypochloraemia, decreased blood pH values (7.26 ± 0.013), HCO3- (15.3 ± 0.71 mmol/L) and AG (2.85 ± 0.084 mmol/L, in healthy people 14.3 ± 1.17 mmol/L). The diagnosis of enteropathy with PLE was confirmed by studies in feces of α1-antitrypsin, which in sick dogs with PLE was more than 22 mg/dL (in clinically healthy dogs up to 18 mg/dL). A treatment regimen with trometamol, Xylat, Disparkol, Voluven, Reopoliglukin, Maropitant, prednisolone, α-lysine escinat, albumin, Presorb and feed additives Vivonex Ten Elemental and Royal Canin Recoveri promotes the recovery of dogs, prevents their death. Under the action of drugs, erythro- and leuсocytopoiesis, protein-synthesizing (the content of total protein and albumin increased by 34.3 and 246.9 %, respectively) and urea-forming functions of hepatocytes improves. We have developed and tested a treatment scheme that restores the acid-base balance of the body, as indicated by the physiological values of blood pH, bicarbonates, anion gap (AG), Na+, K+, Cl- and Mg+.