Abstract
Our everyday lives present us with a continuous stream of multi-modal sensory inputs. While most of this information is soon forgotten, sensory information associated with salient experiences can leave long-lasting memories in our minds. Extensive human and animal research has established that the hippocampus is critically involved in this process of memory formation and consolidation. However, the underlying mechanistic details are still only partially understood. Specifically, the hippocampus has often been suggested to encode information during experience, temporarily store it, and gradually transfer this information to the cortex during sleep. In rodents, ample evidence has supported this notion in the context of spatial memory, yet whether this process adequately describes the consolidation of multi-sensory experiences into memories is unclear. Here, focusing on rodent studies, I examine how multi-sensory experiences are consolidated into long term memories by hippocampal and cortical circuits during sleep. I propose that in contrast to the classical model of memory consolidation, the cortex is a "fast learner" that has a rapid and instructive role in shaping hippocampal-dependent memory consolidation. The proposed model may offer mechanistic insight into memory biasing using sensory cues during sleep.
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