Abstract
Thrombotic Thrombocytopenic Purpura (TTP) is a rare blood-coagulation disorder that causes extensive thrombus formation within the blood vessels. Diagnosis of the disorder is made on the basis of identification of some or all of five clinical features, described as the typical “pentad”: thrombocytopenia, microangiopathic hemolytic anemia, fluctuating neurological symptoms, renal failure, and fever. We report the case of a middle aged female who presented to an urban teaching hospital emergency department. Her initial symptoms of TTP were subtle, making it difficult to achieve a definitive early diagnosis. Awareness of the disorder allowed us to follow through on monitoring for the pentad during the initial period of hospitalization and facilitated the diagnosis, which led to prompt and appropriate treatment. The patient made a complete and sustained recovery. Since prompt institution of plasmapheresis is essential to recovery, we share this case in order to increase the possibility that TTP will be considered in the differential diagnosis of patients presenting with all or part of the total pentad.
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