Abstract
The ability to survive the injection of 200 U/kg of insulin in the presence of food was investigated in rats in which the sensitivity to insulin was either raised by adrenalectomy or reduced by cortisol-treatment. The survival rate following insulin in both adrenalectomized and cortisol-treated rats was not different from that in normal rats, i. e. with free access to food the rats survived, whereas without food all rats died. Insulin (200 U/kg) increased the rate of food intake over 0 to 6 hours in both adrenalectomized and cortisol-treated rats to a level almost identical with that in normal rats (about 3 times higher than the spontaneous rate). Since adrenalectomized and cortisol-treated rats survived 200 U/kg of insulin by a mechanism apparently identical to that in normal rats, it is concluded that in the rat the tolerance to massive doses of insulin is not causally related to the level of insulin sensitivity.
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