Abstract
The technic for isolation perfusion of sarcomas as done at the University of California Medical Center in Los Angeles is described. A total of forty-seven patients have undergone isolation perfusion with the combination of l-sarcolysin (PAM) and actinomycin d as the chemotherapeutic agents; in thirty-two of these patients, positive responses have been obtained. Of this group of patients, four now survive two years or more following perfusion with no evidence of recurrent disease at the present time. New experimental studies are in progress to evaluate the effect of isolation perfusion as an adjunct to surgical excision, and to evaluate the effectiveness of local surgical resection of any tumor masses remaining after a positive response to this therapy.
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