Abstract
The pigmentation of animal skin is controlled by the relative dispersion or aggregation of melanin within the melanocyte. It has been postulated by Lerner (1) that this balance is maintained by the pituitary-pineal axis in the following manner (see Fig. 1): 1. The dispersion of melanin, with a consequent darkening of the skin is induced by the melanocyte-stimulating hormone, alpha MSH, MSH (5) but the lucific effect, due to melatonin, has only been demonstrated in amphibia at this time.
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