Abstract
Prostate Cancer (PCa) is a major global health issue in men over 50 years of age, arising due to complex and often population-specific interactions between genes, environment, and lifestyle. According to GLOBOCAN, PCa incidence in India is on the rise, albeit at a slower rate than that of the global average. This review delves deep into the nuanced relationship between PCa and the genomic landscape of Indian males. The study thoroughly reviews the epidemiology of PCa and examines the contribution of the genetic determinants like polymorphisms, mutations, and methylation patterns; microbial infections as well as the influence of lifestyle habits like diet, smoking, and drinking on the progress and manifestation of cancer among Indian males, thus intending to provide a holistic understanding of the complex interplay driving the malady. This knowledge would not only help us understand the disease mechanisms but also provide a basis for personalized diagnostic, therapeutic, and preventive strategies tailored to India's unique genetic and environmental landscape.
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