Abstract
Measurements have been made of the tensile strengths of physical and formulated mixtures of oxytetracycline and lactose, varying the particle size, temperature and compositions of the mixtures. At a constant packing fraction the tensile strengths of formulated mixtures were higher than those of physical mixtures and both deviated from those expected theoretically; the maximum deviation occurred with the 50:50 mixtures. The tensile strengths of the single powders and the mixtures could be predicted with an average accuracy of ± 10% by the use of equations due to Cheng (1968, 1970) and Kocova and Pilpel (1973).
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