The Targets for Radioprotective and Mitigatory Action of Radio-protector Indralin

Abstract

To analysis the hypothesis accounted for dualistic effect of exogenic nitric oxide on radioprotective and mitigatory properties of radioprotector indralin when it is applied before and after exposure of the organism to ionizing radiation. Expe- riments were conducted on inbred white mature male rats, and female hybrid mice (CBA x C57Bl/6) F1, and inbred white female mice. The rats were exposed to total body gamma- 60 Co irradiation at a supralethal dose of 10 Gy; the abdomen of each rat was partially shielded in the area of the liver. The mice exposed to total body gamma irradiation at lethal and non-lethal doses of 10 and 7 Gy, respectively. Rats and mice were intraperitoneally or orally administered the radioprotector indralin and monizol (isosorbide-5-mononitrate) before or after irradiation. Indralin, administered to rats after irradiation in supralethal dose induced a remarkable increase (up to 76%) in the radioprotective effects achieved by partial shielding of the abdomen of the animal. This potentiating effect of indralin is completely inhibited by monizol (isosorbide-5-mononitrate). Just as, monizol administrated after exposure to radiation can increase radioprotective effects of preventive administration of indralin before irradiation at the lethal dose, and don't influence to them when it is applied before irradiation. Monizol applied after irradiation increases radioprotective properties of radioprotector and blocks its mitigatory action. Mitigatory effect of indralin administrated after irradiation is steeply increased in the condition of the non-uniform irradiation. The mechanism of radioprotective and mitigable effect of indralin is distinguishable.