The TABLET trial: limitations and implications

Chrysoula Dosiou,Alex Stagnaro-Green

doi:10.1186/s12916-019-1365-y

Chrysoula Dosiou, Alex Stagnaro-Green

Open Access

https://doi.org/10.1186/s12916-019-1365-y

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Abstract

The TABLET trial: limitations and implications

Highlights

The link between thyroid antibodies and spontaneous pregnancy loss was published in a seminal paper in 1990
* Correspondence: cdosiou@stanford.edu 1Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Room S025, Stanford, CA 94305, USA Full list of author information is available at the end of the article outcomes
A recent metaanalysis found that the benefit of levothyroxine in reducing miscarriages in euthyroid women with thyroid autoimmunity might only be present in women who conceive naturally, and not in those using assisted reproduction [7]

Summary

Introduction

The link between thyroid antibodies and spontaneous pregnancy loss was published in a seminal paper in 1990. * Correspondence: cdosiou@stanford.edu 1Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Room S025, Stanford, CA 94305, USA Full list of author information is available at the end of the article outcomes. Rates of miscarriage were unusually high in both groups compared with prior studies [3, 6], limiting the generalizability of the results.

Results

Conclusion