PERBANDINGAN PENGGUNAAN BAHAN PENGHANCUR SECARA INTRAGRANULAR, EKSTRAGRANULAR, DAN KOMBINASINYA

Abstract

Rate of d isintegration the tablet is determined by disintegrant position in intragranular or e x tragranular. Intragranulary granules were disintegrant into their constituent particles, while in extragranulary tablets were disintegrant into granul es . This study aims to determine the effectiveness of the addition of materials disintegrant intragranular y , e x tragranular y , and combination on the d isintegration of the tablet with the parameters of physical properties of tablets produced. The tablets were prepared in three formula s based on comparative material s disintegrant variations intragranular and e x tragranular. Comparison of the three formulas in intragranular and e x tragranular : F1 (100%: 0%), F2 (75%: 25%), F3 (0%: 100%). Tablet were prepared using wet granulation method with 10% starch b inder materials. The resulting granule tested physical properties of granule include: flow time, angle of repose , and tapping. Furthermore, compressed with a constantdepth of punch . The tablets tested the physical properties includ e : uniformity of weight, hardness, friability , and disintegration time. Statistical results with oneway ANOVA test showed that between tablets formula have difference disintegra tion time tablet was significant difference with the addition of disintegrant . Data base obtain showed that all formulas parasetamol tablets fulfilled the requirements of granular physical test but only F2 fulfilled the requirements of tablets physical test. The most effective f ormula tablet is F2 (75%:25%) was disintegra tion time (8.05 minute).