Abstract
Abstract: Asiaticoside compound in gotu kola extract ( Centella asiatica (L.) Urban ) and rutin compound in extract of cassava leaves ( Manihot utillissima Pohl.) has been proofed for degenerative diseases treatment. Effervescent tablet was chosen to facilitate the herb gotu kola extract and cassava leaves extract because of fresh sensation and easy to use. The aims of this study was investigated the effect of tartaric acid, sodium bicarbonate, their interactions, and discovered the optimum composition in order to producing effervescent tablets for quality requirements. Quality requirements term in this study were the moisture content of granule, tablet hardness, friability of tablets, dissolution time. The results showed that tartaric acid significantly influenced moisture content of granules, tablets friability, dissolution time of tablets, while sodium bicarbonate significantly affected tablets hardness. Based on super imposed contour plot, the optimum composition for effervescent tablets was at the level 1000 mg tartaric acid and 1120 mg sodium bicarbonate. Keywords : gotu kola extract, cassava leaves extract, effervescent tablet
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