Abstract
The review dwells on the problem of hemostatic disorders in patients undergoing liver transplantation and their correction in the perioperative period. The physiology of the hemostatic system, disorders of the blood coagulation system in patients at various stages of liver transplantation, correction of hemostatic disorders during and after orthotopic liver transplantation are discussed. Liver transplantation is performed in patients with liver diseases in the terminal stage of liver failure. At the same time, changes in the hemostatic system of these patients pose a significant risk of developing bleeding and/or thrombosis during and after liver transplantation. The hypothesis is suggested that the personalized correction of hemostasis disorder in liver transplantation should be based on considerating the nosological forms of the liver damage, mechanisms of development of recipient’s hemostatic disorders, and the stage of the surgery.
Highlights
The first orthotopic liver transplantation (OLT) was performed in Denver, CO (USA) in March 1963 [1]
The list of indications for OLT for half a century of its clinical application has become longer from sev
Changes in the hemostatic system of patients with different liver disease that require it transplantation represent a significant risk of development of thrombosis or bleeding during and after surgery
Summary
The first orthotopic liver transplantation (OLT) was performed in Denver, CO (USA) in March 1963 [1]. The list of indications for OLT for half a century of its clinical application has become longer from sev-. DOI:10.15360/1813-9779-2018-5-58-84 Обзоры операций в мире постоянно растет и показания включают более 50 нозологических форм. Изменения в системе гемостаза пациентов с различными нозологическими формами заболеваний, приводящих к необходимости трансплантации печени, могут представлять собой значительный риск развития, как тромбозов, так и кровотечений во время и после операции трансплантации печени. Причины тромбоза или массивной кровопотери при трансплантации печени носят многофакторный характер и определяются предоперационным состоянием гемостаза у реципиента, а также ролью анестезиологических и хирургических методов
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