Abstract
A novel method to prepare the macrocyclic compound locating substitution derivatives of chitosan was investigated, by using cyclodextrin as the model of macrocyclic compound. The method combines the advantages of activated 6-OH of chitin and high efficiency of click reaction. Chitin C6-OHp-toluenesulfonate (CTN-6-OTs) was generated and subsequently transferred to chitin C6-N3via nucleophilic substitution. Afterwards,β-cyclodextrin was immobilized at 6-OH of chitin via click reaction to afford CTN-6-CD. Ultimately, CTS-6-CD was obtained by removing the acetyl group of chitin unit. The structures and properties of these products were characterized by FTIR, TG, and XRD, respectively. It was found that CTN-6-CD synthesized at the optimum conditions has an immobilized loading of1.6126×10-4 mol/g and that of the corresponding CTS-6-CD, generated by removal of the acetyl group, was1.6891×10-4 mol/g.
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