Abstract

AbstractWe report here that the efficiency of the click chemistry between the terminal azide and alkyne groups of different polymer chains could be drastically increased with the addition of an optimum amount of water into a reaction system. That is, the efficiency was only slightly promoted by the addition of a small amount of water into the reaction mixture. However, the reaction efficiency was increased dramatically near the water volume fraction to lead the reaction mixture into nanosized phase separation. Further increasing in water content caused the polymer(s) to undergo macroscopic phase separation and the click reaction efficiency was decreased once again. The enhanced efficiency of click coupling reaction including conversion and rate was also demonstrated via in-situ 1H-NMR. The reaction kinetics as well as reaction rate constant for these reaction system with typical water content were also evaluated. This finding on enhanced click reaction is of practical value, because click reactions in polymer synthesis are generally more difficult to be carried out and proceed relative slowly at low yield in most case because of the strong steric hindrance effect from “large and long” polymer chains, as compared to “click” reactions which are employed for preparation of the low molecular weight organic compounds.

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