Abstract
Because it had previously been shown that some of the simple n-alkyl-p-carboxybenzamidines possessed significant local anesthetic activity, several new esters were prepared in order to test their activities. Representative examples of halogenated alcohols, aromatic alcohols, and cyclohexanol were chosen for the alcohol portion of the molecule. Several of these new esters were more active than both cocaine when instilled in guinea-pig eyes and procaine when administered intracutaneously in guinea-pig skin. Toxicities were favorable; however, they produced an undesirable pruritis when injected in the forearm of man.
Published Version
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