Abstract
During the study of strains of E. coli deficient in the ability to synthesize thymine, uracil, and an amino acid, we compared nucleic acid syntheses in variously deficient cultures. We observed a slight but significant incorporation of uracil-2-C14 into RNA in the absence of thymine and the essential amino acid. This incorporation, amounting to about 10% of that in the presence of the amino acid, was, in fact, markedly inhibited in the presence of thymine. We therefore supposed that the :meager RNA synthesis was that of messenger RNA, which was affected by a competition between DNA and RNA synthesis for a common template, presumably
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