The synthesis of Fe3O4@SiO2@Pr‐N (CH2CH2OH)3 and Fe3O4@SiO2@Pr‐N (CH2CH2‐ OBuSO3H)3 as nanomagnetic catalysts and their application in the synthesis of tetrahydroacenaphtho[1,2‐b]indolones and docking studies

Abstract

The Fe3O4@SiO2@Pr‐N (CH2CH2‐OBuSO3H)3 as magnetic nanocatalyst with Fe3O4 core has been synthesized and used in the synthesis of tetrahydroacenaphtho[1,2‐b]indolones, which was accomplished through the one‐pot four‐component reaction of 5,5‐dimethyl cyclohexane‐1,3‐dione, acenaphthoquinone, arylamines, and active methylenes under solvent‐free conditions at 80°C. Fe3O4@SiO2@Pr‐N (CH2CH2‐OBuSO3H)3 with high magnetical and nontoxic properties has a core‐shell structure. The molecular docking was performed against the cancer target like the crystal structure of the motor protein kinesin spindle protein in complex with adenosine‐5'‐diphosphate and monastrol (pdb: 1Q0B) (2) and crystal structure of Mcl‐1 in complex with compound 7‐(4‐carboxyphenyl)‐3‐[3‐(naphthalen‐1‐yloxy)propyl]pyrazolo[1,5‐a]pyridine‐2‐carboxylic acid (pdb: 3WIX) (3).