Abstract
<p class="1Body">The emergence of antimicrobial resistance of microorganisms to antibiotics, Also, an increase in nosocomial infections, particularly by <em>Methicillin Resistant Staphylococcus aureus </em>(<em>MRSA</em>), <em>Pseudomonas aeruginosa</em>, the need to discover new antibacterial agents with a mechanism of action different from killing bacteria were more than ever before. The Ag nanoparticles (NPs), ZnO (NPs) and Ag/ZnO (NPs) were synthesized through the thermal decomposition of the precursor of oxalate. Gram-negative antibiotic resistant bacteria and Gram-positive antibiotic resistant bacteria were prepared from the Central laboratory of Rasoul-e-Akram hospital. All of isolates were confirmed by biochemical tests. For determine of antibiotic resistance patterns of isolated, disk diffusion method in accordance with the standard CLSI were used, again. Antibacterial effects of (NPs) against antibiotic resistance bacteria were conducted by MIC and MBC tests. The particles size was less of 50 nm, approximately. Curiously, the silver (NPs) was not exposed the antibacterial properties against all of isolated bacteria. Also, <em>klebsiella pneumonia</em> and <em>MRSA</em> had greatest sensitivity to the ZnO (NPs). Also, Gram-positive antibiotic resistant bacteria showed high sensitivity to Ag/ZnO (NPs), compared to other bacteria. Interestingly, The MBC for ZnO (NPs) against <em>Pseudomonas aeruginosa </em>&gt;= 8192 was observed. The Ag (NPs) had not the ability to inhibit the nosocomial infection. <em>klebsiella pneumonia</em> and <em>MRSA</em> had greatest sensitivity to the ZnO (NPs). Also, Gram-positive antibiotic-resistant bacteria showed high sensitivity to Ag/ZnO (NPs), compared to other bacteria. The Ag/ZnO (NPs) was ability to kill antibiotics resistant bacteria. The antibacterial agents can open a new leaf in our life in the treatment of nosocomial infections.</p>
Highlights
Antibiotic resistance is a worldwide problem (Roberts et al, 2009)
Surface morphology of product was characterized by using a Scanning Electronic Microscopy (SEM, Cam Scan MV 2300, nano-electronics laboratory, Tehran University) with an accelerating voltage of 30 KV (Dabbagh, Moghimipour, Ameri, & Sayfoddin, 2010; Gan, Liu, Zhong, Liu, & Li, 2004)
According to the reports of central laboratory of Rasoul-e-Akram Hospital, Klebsiella pneumonia and Escherichia coli had been isolated from urine samples of patients
Summary
Antibiotic resistance is a worldwide problem (Roberts et al, 2009). World health guidance have described antibiotic-resistant microorganisms as “nightmare bacteria” that “pose a catastrophic threat” to people in every country in the world (Roberts et al, 2009). Many more die from other conditions that were intricate by an antibiotic-resistant infection. Antibiotic-resistant infections add avoidable costs to the already overburdened U.S health care system. In another cases, antibiotic-resistant infections require prolonged treatments, extend hospital stays, necessitate additional doctor visits and result in greater disability and death compared with infections that are treatable with antibiotics (Roberts et al, 2009)
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