Abstract
Summary (1)High cholesterol diet produced xanthomatoses limited to the origins of the major coronary arteries and intramyocardial branches of rabbits. (2)Fractionated X-ray to the hearts of otherwise normal rabbits in the amounts and intervals we employed was apparently responsible for rare areas of medial degeneration and intimal proliferation of major epicardial arteries. (3)Exposure of hearts of rabbits on high cholesterol diets to fractionated doses of X-ray produced diffuse severe arteriosclerotic and atherosclerotic lesions of major epicardial coronary arteries. (4)Synergism between a physical agent (X-ray) and a chemical substance (cholesterol) were apparently necessary to evoke this effect. Deposition of lipid in portions of vessels damaged by X-irradiation was probably one of the prime mechanisms in the genesis of these lesions. (5)In the elderly patient in whom frank or incipient vessel damage was already present, the tissue damaging effect of the X-irradiation may have accelerated the development of the coronary arteriosclerosis.
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