The study of the physicochemical properties of rectal cream samples with the carrot extract and rutin

Abstract

The modern arsenal of drugs aimed at eliminating pathological processes of the anorectal zone, as a rule, consists of suppositories and soft drugs. When using suppositories, hemorrhoidal nodes may be injured, uneven distribution of the drug along the walls of the anal canal may be observed. In addition, with external and combined hemorrhoids, there is a need to apply the drug not only to the walls of the anal canal, but also to the perianal skin. Therefore, preference is given to the use of soft drugs since the process of their introduction is as easy as possible. Today, the pharmaceutical market of Ukraine has a wide range of products for the treatment of diseases of the anorectal zone, but the constant increase in the number of patients indicates that this problem has not been solved. Therefore, the study on the creation of a new rectal soft medicine that will have a complex effect on pathological processes and expand the range of domestic drugs for use in proctology is relevant. Aim. To substantiate the type of base for a soft rectal medicine by studying the organoleptic and physicochemical properties of the experimental samples. Materials and methods. The study objects were samples of a soft dosage form of various compositions and the reference drug “Procto-Glivenol Cream” (VAMPHARMA S.R.L., Italy). Samples on different carrier bases were examined by their organoleptic and textural properties; their colloidal and thermal stability, viscosity and pH were studied. Results and discussion. It has been found that the use of a sample on a gel base with Aristoflex does not ensure the presence of an optimal adhesive layer between the mucous membrane of the anorectal zone and the dispersion medium of the drug. The proxanol-188 sample does not have satisfactory thermal and colloidal stability indicators. The use of an emulsion base provides the necessary ability to spread over the surface, adhesion and cohesion. Conclusions. Therefore, for further research, it is advisable to use a sample of the rectal cream, which is an emulsion system.