Abstract
The study of the effect of the low molecular analog of neuropeptide Y on behavioral reactions in rats
Highlights
Materials and methodsThe study object was a modified terminal neuropeptide Y (NPY) fragment containing 9 amino acid residues
Відомо, що поряд з основними стрес-адаптивними системами організму одне з вирішальних місць посідає біологічно активний пептид – нейропептид Y (NPY)
The data obtained indicate that the neuropeptide Y modified fragment is able to affect the anxiety level and research activity of rats; it substantiates the feasibility of further studies of this experimental compound
Summary
The study object was a modified terminal NPY fragment containing 9 amino acid residues. The experimental animals received intranasally a solution of the peptide studied in the dose of 0.02 mg/kg, 0.05 mg/kg and 0.1 mg/kg. The pharmacological study of the effect of the compound on the behavioral reactions of rats was performed using the tests “open field” and “elevated plus-maze”
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