Abstract
In the industrial production of the hop infructescence dry extract, the non-polar fraction in the form of a lipophilic extract obtained by extraction with heptane or hexane remains as a waste. The lipophilic extract obtained under such conditions is characterized by a significant content of biologically active substances from the groups of terpene alcohols, aldehydes, ketones, epoxides, acids, and esters. In this case, it is promising to use the lipophilic extract in further research on the development of new drugs, and it will also provide a comprehensive treatment of hop infructescences.Aim. To study the chemical composition of the lipophilic hop extract by gas chromatography for further standardization and use as a constituent of finished dosage forms.Materials and methods. The lipophilic hop extract was obtained at the SPC “Borshchagovsky CPP”, Kyiv. The chemical composition of the lipophilic fraction of hop infructescences was studied according to the requirements of the State Pharmacopoeia by gas chromatography with a flame ionization detector using an Agilent 7890 GC gas chromatograph with a 597 Agilent GC/MSD mass spectrometric detector.Results. According to the results of the studies conducted, using library spectra, 47 volatile compounds were identified in the lipophilic hop extract. The main components were (S)-3-ethyl-4-methylpentanol, 1,3,3-trimethyl-bicyclo [2,2,1] heptane-2-one, eicosamethyl-cyclodecasiloxane, 4-pentene-2-ol, Z-7-hexadecanoic acid, phthalic acid esters, 7-tetradecenal, CIS-11-hexadecenal, their content reached 75% of the area of all peaks of substances.Conclusions. In the lipophilic hop extract, the content of volatile substances has been identified and quantified by gas chromatography with a mass spectrometric detector. The major representatives of the substances are (S)-3-ethyl-4-methylpentanol and 1,3,3-trimethyl-bicyclo[2,2,1]heptane-2-one, their content is 49.5 % of the total amount of substances.
Highlights
При промисловому виробництві сухого екстракту суплідь хмелю як відходи залишається неполярна фракція у вигляді ліпофільного екстракту, одержаного екстракцією гептаном або гексаном
The lipophilic hop extract was obtained at the SPC “Borshchagovsky CPP”, Kyiv
The chemical composition of the lipophilic fraction of hop infructescences was studied according to the requirements of the State Pharmacopoeia by gas chromatography with a flame ionization detector using an Agilent 7890 GC gas chromatograph with a 597 Agilent GC/MSD mass spectrometric detector
Summary
The lipophilic hop extract was obtained at the SPC “Borshchagovsky CPP”, Kyiv. The chemical composition of the lipophilic fraction of hop infructescences was studied according to the requirements of the State Pharmacopoeia by gas chromatography with a flame ionization detector using an Agilent 7890 GC gas chromatograph with a 597 Agilent GC/MSD mass spectrometric detector.
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