Abstract
The study of the antihypoxic activity of new derivatives of benzilic acid
Highlights
On the model of acute normobaric hypoxic hypoxia with hypercapnia the antihypoxic action of new derivatives of benzilic acid, namely – N-heterylamides of benzilic acid and products of their intramolecular cyclodehydration – thienolactams with five, six- and seven membered cycles, respectively
The aim of this work was to determine the antihypoxic activity of the new pharmacologically active compounds synthesized in the range of benzilic acid derivatives
The data obtained in the study of the antihypoxic activity of the new pharmacologically active compounds synthesized in the range of benzilic acid derivatives are given in Table and Fig. 1, 2
Summary
On the model of acute normobaric hypoxic hypoxia with hypercapnia the antihypoxic action of new derivatives of benzilic acid, namely – N-heterylamides of benzilic acid and products of their intramolecular cyclodehydration – thienolactams with five-, six- and seven membered cycles, respectively. It should be noted that modification of the ester group in position 6 of 2-oxo-3,3-diphenyl-2,3-dihydro-1Н-thieno[3,4-b]pyrrole-6-carboxylic acid appeared to be appropriate. Amides based on this compound (KMS-68, KMS-69, KMS-71) during the experiment showed the maximum life span of the animals under research. Hypoxia occurs with the lack of oxygen in the inhaled air and blood, as well as in disturbance of the biochemical processes of tissue respiration. Because of this oxygen deficiency the irreversible changes occur in organs. The aim of this work was to determine the antihypoxic activity of the new pharmacologically active compounds synthesized in the range of benzilic acid derivatives
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