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Abstract
Extracts were obtained from raw materials of cultivated plants from family Rosaceae and pharmacological screening was carried out. It was found that extract of cherry shoots showed diuretic activity higher than the comparator hypothiazide at a dose of 100 mg / kg, extracts from cherry and apricot leaves had significant anti-inflammatory activity in a dose of 25 mg / kg, extract from peach leaves showed immunotropic activity in low concentration of 0.4 mg / ml detected in vitro These extracts are promising for further study and creation of new medicines on their basis. Composition and content of free amino acids in the dry extracts obtained from the leaves and shoots of cherry, leaves of apricot and soft extract from peach leaves were determined by HPLC. The presence of 21 amino acids of which eight are essential - threonine, valine, isoleucine, leucine, phenylalanine, histidine, lysine and arginine, was established. Proline, asparagine, γ-aminobutyric and glutamic acids, arginine and alanine prevailed. All extracts were free from cystine and methionine and only extracts from the leaves of cherry and peach contained cysteine in small amount. The dry extract of cherry shoots had the largest amount of amino acids - 3154.2 mg / L, the lowest - the extract from apricot leaves - 605.9 mg / L.
Highlights
The extracts have been obtained from the raw material of cultivated plants from Rosaceae family, and their pharmacological screening has been carried out
It has been found that the extract of cherry shoots shows the diuretic activity that is higher than the activity of the reference drug hypothiazide in the dose of 100 mg/kg, the extracts from cherry and apricot leaves possess a significant anti-inflammatory activity in the dose of 25 mg/kg, and the extract from peach leaves shows the immunotropic activity in the low concentration of 0.4 mg/ml detected in vitro [5,6,7,8,9,10]
The results of qualitative and quantitative analysis of free amino acids in the extracts are shown in Table, chromatograms are given in Fig. As can be seen from Table, the total content of free amino acid was the highest in the extract obtained from cherry shoots, and the extract obtained from apricot leaves had the lowest amount
Summary
The extracts have been obtained from the raw material of cultivated plants from Rosaceae family, and their pharmacological screening has been carried out. It has been found that the extract of cherry shoots shows the diuretic activity that is higher than the activity of the reference drug hypothiazide in the dose of 100 mg/kg, the extracts from cherry and apricot leaves possess a significant anti-inflammatory activity in the dose of 25 mg/kg, and the extract from peach leaves shows the immunotropic activity in the low concentration of 0.4 mg/ml detected in vitro These extracts are promising for further study and creation of new medicines on their basis. In nature there are a great number of amino acids found in a free state, as well as components of proteins, peptides, enzyme systems, hormones, etc They can form complexes with other compounds and affect their bioavailability and pharmacological effect. The aim of our research was a comparative study of the amino acid composition of the extracts obtained from leaves and shoots of cherry, leaves of apricot and peach
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